Relapsed/Refractory

4

Review clinical trials related to Relapsed/Refractory. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

IASO206 in Patients With Relapsed/Refractory Autoimmune Hemolytic Anemia

This study is an open-label, single-arm early exploratory clinical study, aiming to evaluate the safety, tolerability and preliminary efficacy of IASO206 Injection (In Vivo CAR-T) in Patients with Relapsed/Refractory Autoimmune Hemolytic Anemia

Participants needed: 18
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Institute of Hematology & Blood Diseases Hospital, ChinaUpdated: May 13, 2026
Eligibility criteria

Age 18 to 75 years, gender unrestricted. [+7]

Subject with confirmed lymphoproliferative neoplasms. [+29]

Status: Recruiting

Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab

To learn about the safety of giving the drug brexucabtagene autoleucel to participants with relapsed/refractory B-cell ALL after treatment with inotuzumab ozogamicin, blinatumomab, and either hyper-CVAD or mini-hyper-CVD. Also, to learn if giving brexucabtagene autoleucel to patients with relapsed/refractory or high-risk, newly diagnosed B-cell ALL after treatment with inotuzumab ozogamicin, blinatumomab, and either hyper-CVAD or mini-hyper-CVD can help to control the disease.

Participants needed: 40
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: M.D. Anderson Cancer CenterUpdated: Apr 24, 2026Locations: 1
Eligibility criteria

Participants of age ≥18 years with documented relapsed or refractory B-cell ALL [+8]

Philadelphia positive B-cell ALL [+5]

Status: Recruiting

A Study to Evaluate CG-105-12 in Patients With Relapsed/Refractory Multiple Myeloma

This study is a single-centre, single-arm, open-label, dose-escalation exploratory study with single-dose administration. Its objective is to evaluate the safety, tolerability, dose, anti-tumor efficacy, and pharmacokinetic characteristics of CG-105-12 in the participants with BCMA-positive relapsed/refractory multiple myeloma who previously received adequate but uneffective standard treatments.

Participants needed: 12
Trial details
Phase: Early Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital of Nanchang UniversityUpdated: May 31, 2025Locations: 1
Eligibility criteria

1.Aged 18-75 years (inclusive of 18 and 75 years old), gender not limited; [+18]

1.Hepatitis B surface antigen (HBsAg) positive, or Hepatitis B core antibody (HB... [+21]

Status: Recruiting

Chimeric Antigen Receptor Modified T Cells Targeting BCMA for the Treatment of Relapsed/Refractory Multiple Myeloma

To evaluate the safety and tolerability of chimeric antigen receptor gene-modified T cells targeting BCMA for the treatment of relapsed/refractory multiple myeloma

Participants needed: 5
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital of Xiamen UniversityUpdated: Sep 25, 2024Locations: 1
Eligibility criteria

Age 18-80 years, no gender restrictions; [+8]

Pregnant or nursing women, as well as women planning to become pregnant within t... [+11]