This study is a prospective, randomized, comparative clinical trial conducted by Wuhan Union Hospital and aim to compare the therapeutic effects of Mitomycin and Lobaplatin in the treatment of advanced colorectal cancer patients with radical surgery combined with hyperthermic intraperitoneal chemotherapy
No chemoradiotherapy or other anti-tumor therapy before clinical trial performed;
Aged 18-75 years;
Male or non-pregnant or lactating women;
Pathological diagnosis of colorectal adenocarcinoma;
A history of other malignant tumors within 5 years;
Distant metastasis found during surgery;
Allergic to paclitaxel, lobaplatin and other related chemotherapeutic drugs;
Suffering from epilepsy or other mental illness, unable to control behavior;