Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

ConditionRosacea
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorWright State University

About this trial

Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. The purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea.

Eligibility criteria

Qualifiers

Fitzpatrick Skin Type I - IIII

Self-identified rosacea or no history of flushing/blushing for controls

Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.

Disqualifiers

Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)

Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)

Large tattoos in the designated testing areas

Tanning bed use within last 3 months

Trial design

Treatments tested in this trial

  • Imipramine
  • Amitriptyline
  • Vehicle

Treatment groups

48 Participants
are divided into 2 treatment groups

Sponsors and collaborators