Adolescents and young adults undergoing spinal fusion surgery for the correction of scoliosis and other spinal deformity are at high risk of perioperative iron deficiency and anemia, yet the means and evidence for optimizing iron status have not been described in this setting. The proposed study is a randomized controlled trial of preoperative intravenous iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in this vulnerable population. Building evidence for patient blood management interventions such as iron supplementation is vital to ensuring high quality care of surgical patients and may reduce unnecessary transfusions amid recent blood shortages.
10 -19 years old
diagnosis of scoliosis or kyphosis
scheduled for imminent spinal fusion procedure (<6 weeks) at MS-CHONY
Iron deficiency or hypoferritinemia, defined as serum ferritin less than or equal to 50 μg/L
C-reactive protein > 10 mg/L
receiving nutritional support by report in the medical chart
self-reported history of hypersensitivity reaction to iron-containing supplements
self-reported history of receiving intravenous iron supplements
Columbia University
Lead sponsor
Association for the Advancement of Blood & Biotherapies
Collaborator