This is a domestic exploratory, single-arm clinical study enrolling patients with histologically or cytologically confirmed locally advanced esophageal squamous cell carcinoma (ESCC), aiming to evaluate the efficacy and safety of neoadjuvant adebrelimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma (ESCC).
Provided written informed consent and voluntarily enrolled in this study;
Aged 18-75 years, male or female;
Histologically or cytologically confirmed esophageal squamous cell carcinoma (ESCC);
Clinical stage: cT1b-cT2N+M0 or cT3-cT4a any N M0;
Significant tumor invasion into adjacent organs of the esophageal lesion (e.g., major arteries or trachea);
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage;
Poor nutritional status with a Body Mass Index <18.5 kg/m² (BMI <18.5 kg/m²); subjects whose BMI is corrected with targeted nutritional support prior to randomization may be considered for enrollment at the discretion of the principal investigator;
History of hypersensitivity to monoclonal antibodies, any component of adebrelimab, paclitaxel, cisplatin, or other platinum-based agents;