Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorRutgers, The State University of New Jersey

About this trial

The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% in painful non-spinal bone metastases. Additionally, the investigators hypothesize that utilizing a fractionation scheme with an escalated biologically equivalent dose (BED) will result in a higher proportion of participants responding to treatment, and will also lead to more durable responses. Furthermore, the investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 35-45% in painful non-bone metastases

Eligibility criteria

Qualifiers

Have provided signed informed consent for the trial

Aged ≥18 years at the time of informed consent

Histologic proof of malignancy

Radiologic or histologic evidence of bone metastases or non-bone metastases

Disqualifiers

Metastasis from a highly radiosensitive tumor (eg, lymphoma, myeloma, germ cell tumor)

Spinal metastasis

Active compression of spinal cord/cauda equina

Previous RT or SBRT to the same site

Trial design

Treatments tested in this trial

  • EXTERNAL BEAM RADIATION

Treatment groups

124 Participants
are divided into 2 treatment groups