About this trial
The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% in painful non-spinal bone metastases. Additionally, the investigators hypothesize that utilizing a fractionation scheme with an escalated biologically equivalent dose (BED) will result in a higher proportion of participants responding to treatment, and will also lead to more durable responses. Furthermore, the investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 35-45% in painful non-bone metastases
Eligibility criteria
Qualifiers
Have provided signed informed consent for the trial
Aged ≥18 years at the time of informed consent
Histologic proof of malignancy
Radiologic or histologic evidence of bone metastases or non-bone metastases
Disqualifiers
Metastasis from a highly radiosensitive tumor (eg, lymphoma, myeloma, germ cell tumor)
Spinal metastasis
Active compression of spinal cord/cauda equina
Previous RT or SBRT to the same site
Trial design
Treatments tested in this trial
- EXTERNAL BEAM RADIATION