About this trial
The goal of this clinical trial is to compare the use of veno-arterial extracorporeal membrane oxygenation (VA ECMO) with and without left ventricular (LV) unloading in patients being treated for cardiogenic shock (CS). The main aims of the study are:
1. To determine the physiologic effects on cardiopulmonary congestion of adding LV unloading to VA ECMO 2. To determine the effects on myocardial function of adding LV unloading to ECMO 3. To test the effects on myocardial recovery of adding LV unloading to VA ECMO
Participants who are being treated with VA ECMO will be randomized to receive or not receive LV unloading in the form of an intra-aortic balloon pump (IABP). Over the course of the study, the investigators will obtain measurements via lab work, echocardiography, and pulmonary artery catheter that will allow comparison of the two groups.
Eligibility criteria
Qualifiers
Adult patients (age 18 years or older)
Diagnosis of acute cardiogenic shock (CS)
Society for Coronary Angiography and Interventions (SCAI) Stage C or greater
2 or more inotropic medications and not improving
Disqualifiers
Metastatic or stage 4 cancer
Atrial septostomy
Planned LV unloading on ECMO
Anticipated death <72 hours
Trial design
Treatments tested in this trial
- IABP
Treatment groups
Sponsors and collaborators
University of Utah
Lead sponsor
University of Minnesota
Collaborator