Tranexamic Acid for Anaemia Trial

ConditionAnemia
Trial statusNot yet recruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age18+
SponsorLondon School of Hygiene and Tropical Medicine

About this trial

Anaemia is a common health problem in women. It is often due to iron deficiency. Anaemia is a particular problem during pregnancy and is bad for the mother and baby. It is best to treat anaemia in young women well before they get pregnant. Doctors treat anaemia with iron and vitamins. But some people get side effects when taking iron tablets and so they stop taking them. Heavy menstrual periods are a common cause of iron deficiency and even if women do take iron, because they lose so much iron in their periods, they still become iron deficient. Tranexamic acid (TXA) is a medicine used to treat heavy periods. The investigators of this study would like to find out if taking TXA with the usual iron and vitamin supplements is better at treating anaemia than taking iron and vitamin supplements alone. (Lay Summary)

Eligibility criteria

Qualifiers

Adult women (aged 18 years and older)

Having menstrual periods every 21 to 38 days that last 2 to 9 days

Having anaemia (Hb < 120 g/L) according to point-of-care finger prick screening test

Willing to provide informed consent and able to attend study visits during the trial period

Disqualifiers

Planning to get pregnant during trial period

Already taking TXA

Known to have contraindications to TXA treatment (including allergy to TXA or its excipients, renal impairment, active thromboembolic disease, history of venous or arterial thrombosis, history of convulsion.)

Trial design

Treatments tested in this trial

  • Tranexamic Acid 500 MG
  • Matched placebo

Treatment groups

4,000 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

London School of Hygiene and Tropical Medicine

Lead sponsor

The Jon Moulton Charity Trust

Collaborator