Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age40-75
SponsorNanjing First Hospital, Nanjing Medical University
About this trial
The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery. The main questions it aims to answer are:
Does dexmedetomidine or esketamine prevent the development of postoperative sleep disturbances? Which one works better? The researchers compared dexmedetomidine and esketamine with saline (a drug-free solvent) to see if dexmedetomidine and esketamine prevented the development of postoperative sleep disturbances.
Participants will:
1. Intraoperative continuous infusion of dexmedetomidine, esketamine or saline until the end of surgery 2. Postoperative sleep was assessed on the first and third postoperative days using a sleep rating scale
Eligibility criteria
Qualifiers
ASA class II-III, NYHA class I-III, EF ≥ 50%
Intended to perform cardiac surgery under extracorporeal circulation
Disqualifiers
Patients undergoing second heart surgery
Patients with mental retardation, deafness, or other conditions that interfere with normal communication
Previous neurological or psychiatric disorders
Patients with a history of sleep disorders
Trial design
Treatments tested in this trial
- Intraoperative infusion of dexmedetomidine
- Intraoperative infusion of esketamine
- Saline control
Treatment groups
180 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov