The aim of the study is to assess the effectiveness and tolerance of pain treatment in AP in children using intravenous paracetamol in combination with ibuprofen or paracetamol in combination with metamizole. The study is prospective, interventional, and randomized.
diagnosis of AP according to the INSPPIRE mentioned above criteria,
age from 3 to 18 years of age,
abdominal pain on admission assessed on the Numerical Rating Scale (NRS) or FLACC >= 4 points,
no analgesic treatment before enrolment in the study OR the last dose of analgesic drug (paracetamol, ibuprofen, metamizole) taken ≥ 6 hours before enrolment for examination,
who took the last dose of painkiller (paracetamol, ibuprofen, metamizole) < 6 hours before entering the study,
allergic to acetylsalicylic acid, other NSAIDs, paracetamol, metamizole,
with inflammatory bowel disease,
with gastrointestinal bleeding and other active bleeding,