Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age65+
SponsorWestern University, Canada
About this trial
Type 2 diabetes and low levels of physical activity are associated with an increased risk of cognitive decline in older adults. Improving blood sugar control and engaging in regular exercise may help support brain health and physical function in this population.
The MOTIVATE study is a randomized clinical trial designed to examine the effects of supervised exercise and diabetes treatment with semaglutide, alone or in combination, on cognitive function, physical health, and brain-related outcomes in older adults with Type 2 diabetes. Participants will be assigned to one of four study groups involving exercise training, control exercise, semaglutide treatment, or standard diabetes care.
Participants will complete supervised exercise sessions three times per week for 32 weeks, with some participants also receiving weekly semaglutide injections for 16 weeks. Assessments will include cognitive testing, physical and functional measures, blood-based metabolic markers, and brain imaging. This study aims to improve understanding of how exercise and diabetes treatments may support brain health in older adults with Type 2 diabetes.
Eligibility criteria
Qualifiers
Informed consent obtained before any trial-related activities. Trial-related activities are any procedures that are carried out as part of the trial, including activities to determine suitability for the trial.
Community-dwelling
Male or female
Age ≥ 65 at the time of signing informed consent
Disqualifiers
Have a medical condition for which semaglutide or exercise is contraindicated
Use of a GLP-1 receptor agonist in the past 6 months (i.e., offers removal of Semaglutide from the system as it has a half-life of around 1 week; thus, 8-10 weeks are required for a washout.
Trial design
Treatments tested in this trial
- semaglutide
- Moderate-Intensity Resistance Exercise
- Balance and Tone (BAT) Exercise
Treatment groups
164 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov