Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMeri Mirceta

About this trial

Effective pain management after abdominal surgery is essential for recovery. This study compares two pain relief methods-intrathecal morphine (a single spinal injection) and continuous epidural analgesia-for patients undergoing minimally invasive colorectal cancer surgery.

The investigators expect intrathecal morphine to provide better pain relief at rest 24 hours after surgery, while epidural analgesia may be more effective during movement. By 48 to 72 hours, both methods should offer similar pain control. The epidural group may require fewer additional pain medications but could experience more side effects, including a higher risk of low blood pressure and technical difficulties. Additionally, these patients may have a slightly longer hospital stay. In contrast, the intrathecal morphine group may have fewer overall side effects. Despite these differences, patient satisfaction, sleep quality, and recovery are expected to be similar in both groups.

By evaluating these methods, this study aims to determine the most effective and safe approach to post-surgical pain management, improving comfort and recovery outcomes for patients.

Eligibility criteria

Qualifiers

Male or female patients with colorectal carcinoma undergoing laparoscopic abdominal surgery aged 18-80 years, ASA classification I-III, Body Mass Index (BMI) 15-35 kg/m2.

Disqualifiers

abnormal coagulation function, defined as prothrombin time or activated partial prothrombin time above standard laboratory values or an international normalised ratio (INR) ≥1.4; or receiving ongoing therapeutic anticoagulation,

thrombocytopenia, defined as a platelet count <80×10 9 L-1,

pre-existing skin infection at the neuraxial anesthesia puncture site,

pre-existing neurologic deficit, including peripheral neuropathy,

Trial design

Treatments tested in this trial

  • Intrathecal Morphine
  • Epidural Analgesia

Treatment groups

98 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Meri Mirceta

Lead sponsor

University Hospital of Split

Sponsor institution