Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery

Effective pain management after abdominal surgery is essential for recovery. This study compares two pain relief methods-intrathecal morphine (a single spinal injection) and continuous epidural analgesia-for patients undergoing open colorectal cancer surgery. The investigators expect intrathecal morphine to provide equal pain relief at rest 24 hours after surgery, while epidural analgesia may be more effective during movement. By 48 to 72 hours, both methods should offer similar pain control. The epidural group may require fewer additional pain medications but could experience more side effects, including a higher risk of low blood pressure and technical difficulties. Additionally, these patients may have a slightly longer hospital stay. In contrast, the intrathecal morphine group may have fewer overall side effects. Despite these differences, patient satisfaction, sleep quality, and recovery are expected to be similar in both groups. By evaluating these methods, this study aims to determine the most effective and safe approach to post-surgical pain management, improving comfort and recovery outcomes for patients.

Participants needed: 98
Trial details
Phase: Phase 4Age: 18-80Biological sex: AllType: InterventionalSponsor: Meri MircetaUpdated: Apr 20, 2025Locations: 1
Eligibility criteria

Male or female patients with colorectal carcinoma undergoing laparoscopic abdomi...

abnormal coagulation function, defined as prothrombin time or activated partial... [+7]

Status: Not yet recruiting

Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery

Effective pain management after abdominal surgery is essential for recovery. This study compares two pain relief methods-intrathecal morphine (a single spinal injection) and continuous epidural analgesia-for patients undergoing minimally invasive colorectal cancer surgery. The investigators expect intrathecal morphine to provide better pain relief at rest 24 hours after surgery, while epidural analgesia may be more effective during movement. By 48 to 72 hours, both methods should offer similar pain control. The epidural group may require fewer additional pain medications but could experience more side effects, including a higher risk of low blood pressure and technical difficulties. Additionally, these patients may have a slightly longer hospital stay. In contrast, the intrathecal morphine group may have fewer overall side effects. Despite these differences, patient satisfaction, sleep quality, and recovery are expected to be similar in both groups. By evaluating these methods, this study aims to determine the most effective and safe approach to post-surgical pain management, improving comfort and recovery outcomes for patients.

Participants needed: 98
Trial details
Phase: Phase 4Age: 18-80Biological sex: AllType: InterventionalSponsor: Meri MircetaUpdated: Mar 18, 2025Locations: 1
Eligibility criteria

Male or female patients with colorectal carcinoma undergoing laparoscopic abdomi...

abnormal coagulation function, defined as prothrombin time or activated partial... [+7]