Safety of Short-course of NSAIDs in Pediatric Patients With CKD
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-25
SponsorUniversity of Colorado, Denver
About this trial
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This is currently in the process of developing multi institution collaboration within a Pediatric Urology population, intended to inform future work in a larger patient population.
Eligibility criteria
Qualifiers
Patients over 18 months of age
diagnosis of CKD stages 2-3a, confirmed by CKiD U25 eGFR calculator based on cystatin C laboratory testing within 6 months of surgery
Patient is scheduled to undergo a urologic surgery requiring admission or overnight stay in the hospital
Disqualifiers
Diagnosis of CKD stage 1 or 4-5
Past medical history of renal transplant
Past medical history of nasal polyp
Procedure for oncologic indications or on chemotherapy
Trial design
Treatments tested in this trial
- NSAIDs
- Placebo
Treatment groups
164 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov