About this trial
Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid. After vaginal delivery, the umbilical cord is clamped and cut after a delay that allows some of the blood in the umbilical cord and placenta to flow back into the baby. Meanwhile, as the baby breathes for the first time, the lungs fill with air and more fluid is pushed out. However, it does not always work out that way.
A baby born prematurely may have breathing problems because of extra fluid staying in the lungs related to the immaturity of the lung structure. Thus, the baby must breathe quicker and harder to get enough oxygen enter into the lungs. The newborn is separated from the mother to provide emergency respiratory support. Although the baby is usually getting better within one or two days, the treatment requires close monitoring, breathing help, and nutritional help as the baby is too tired to suck and swallow milk. Sometimes, the baby cannot recover well and show greater trouble breathing needing intensive care. This further separates the mother and her baby. A possible mean to help the baby to adapt better after a premature birth while staying close to the mother is to delay cord clamping when efficient breathing is established, either spontaneously or after receiving breathing help at birth. In this study, we intend to test this procedure in moderate or late preterm infants and see whether the technique helps the baby to better adapt after birth and to better initiate a deep bond with the mother.
Eligibility criteria
Qualifiers
The delivery takes place between 32 0/7 and 36 6/7 weeks of gestation
They carry singletons
Disqualifiers
Fetal anomalies including congenital malformations, anemia, and growth restriction with abnormal Dopplers.
Abnormal placentation such as placenta previa.
Signs of fetal distress necessitating an emergency cesarean section.
Maternal health issue including severe anemia (defined as hemoglobin level < 7 g/dL), preeclampsia, and bleeding disorders.
Trial design
Treatments tested in this trial
- Physiological Based Cord Clamping
- Differed Cord Clamping
Treatment groups
Sponsors and collaborators
Queen Fabiola Children's University Hospital
Lead sponsor
The Belgian Kids Fund
Collaborator
Fonds IRIS-Recherche
Collaborator
Ars Statistica
Collaborator