Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorRush University Medical Center

About this trial

Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.

Eligibility criteria

Qualifiers

Adult, age ≥ 18 years old

Receiving invasive mechanical ventilation for ≥24 hours

BMI ≥40 kg/m2

Undergoing planned extubation per treating team

Disqualifiers

Pregnant

Use of extra-corporeal membrane oxygenation

Chronic tracheostomy in place

Unplanned or accidental extubation

Trial design

Treatments tested in this trial

  • Noninvasive ventilation alternating with high flow nasal cannula
  • High flow nasal cannula

Treatment groups

250 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Rush University Medical Center

Lead sponsor

Hospital Civil de Guadalajara

Collaborator

Medical College of Wisconsin

Collaborator

The University of Texas Health Science Center, Houston

Collaborator

Central DuPage Hospital

Collaborator