About this trial
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
Eligibility criteria
Qualifiers
Adult, age ≥ 18 years old
Receiving invasive mechanical ventilation for ≥24 hours
BMI ≥40 kg/m2
Undergoing planned extubation per treating team
Disqualifiers
Pregnant
Use of extra-corporeal membrane oxygenation
Chronic tracheostomy in place
Unplanned or accidental extubation
Trial design
Treatments tested in this trial
- Noninvasive ventilation alternating with high flow nasal cannula
- High flow nasal cannula
Treatment groups
Sponsors and collaborators
Rush University Medical Center
Lead sponsor
Hospital Civil de Guadalajara
Collaborator
Medical College of Wisconsin
Collaborator
The University of Texas Health Science Center, Houston
Collaborator
Central DuPage Hospital
Collaborator