As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens.
Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .
Age 50-80 years (both male and female)
Relatively healthy and in stable health condition
Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
VO₂peak below the 75th percentile for age- and sex-specific norms
Significant change in medication in the past 3 months
History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
National University of Singapore
Lead sponsor
Xprize Foundation
Collaborator
Abinopharm, Inc
Collaborator
DoNotAge.org
Collaborator