Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire Vaudois

About this trial

Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.

This study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.

Eligibility criteria

Qualifiers

Patients scheduled for elective orthopaedic surgery on the upper limb

Patients scheduled for elective orthopaedic surgery on the lower limb.

Score ASA I-III; Patients aged over 18 years; Signed informed consent.

Surgery under general anaesthesia or under sedation

Disqualifiers

Refusal or inability to understand the informed consent

Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone

Patients with long term opioid treatment

Bleeding diathesis

Trial design

Treatments tested in this trial

  • Morphine provided via oral PCA
  • Morphine provided via oral PCA + morphine administered at a scheduled regimen

Treatment groups

100 Participants
are divided into 2 treatment groups