Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorPeking Union Medical College Hospital
About this trial
Intra-abdominal infection is one of the most serious complications after pancreatic resection. The preventive use of antibiotics intraoperatively could reduce the incidence rate of postoperative intra-abdominal infection. According to the previous retrospective study, changes of serum lactate level on postoperative day1 could predict the incidence rate of postoperative intra-abdominal infection. This prospective RCT is to further validate and promote the findings and conclusion.
Eligibility criteria
Qualifiers
treatment by pancreatic resection, including pancreaticoduodenectomy, pancreatosplenectomy, total pancreatectomy, and other variant operations;
revival in the intensive care unit (ICU) with standard serum lactate elution treatments after surgery instead of the operation room or general ward;
availability of complete preoperative, intraoperative, and postoperative data;
the peak serum lactate level in 24 hours after surgery >3.250 mmol/L.
Disqualifiers
a history of surgical treatment of any upper abdominal lesions before the current hospital admission;
the minimum mean arterial pressure <65 mmHg during the operation;
without written informed consents for the perioperative situation and related studies.
Trial design
Treatments tested in this trial
- Preventive use of advanced antibiotics
- Routine
Treatment groups
297 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov