This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration, diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center.
Biological samples, including peripheral blood, tears, aqueous humor, vitreous humor, and subretinal fluid, will be collected during routine clinical and surgical procedures. Advanced clinical proteomics approaches will be applied to characterize molecular signatures associated with disease onset, progression, and response to treatment.
The study seeks to improve the understanding of disease pathophysiology and support the development of novel diagnostic and prognostic biomarkers in ophthalmology.
Age ≥ 18 years
Ability to understand the study procedures and provide written informed consent
Willingness and ability to comply with study procedures and visits
Patients with age-related macular degeneration (intermediate or advanced, including geographic atrophy or neovascular AMD)
Age < 18 years
Presence of infectious ocular diseases
Alterations in the electrophoretic profile of gamma globulins