Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

About this trial

The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening. The study includes healthy individuals, patients at risk of cancer, and patients with diagnosed cancers. The main questions it aims to answer are:

* Evaluating the deep-learning model's accuracy and specificity in identifying cancer-specific features in Raman spectral data and determining whether this method can accurately classify patients based on risk. * Identifying which model is more adaptable to the Raman spectrum * Providing an interpretable analysis of the model-generated diagnosis Participants are already being diagnosed and follow-up to determine the type of cancer.

Eligibility criteria

Qualifiers

Histopathological diagnosis of malignant tumors, including colorectal cancer, gastric cancer, hepatic cancer, pancreatic cancer, and esophageal cancer.

Patients in normal physiological conditions without any malignant tumors or precancerous lesions.

Patients with malignant tumor without recieving any interventions, including chemotherapy, surgery, radiotherapy, immunotherapy or other anti-tumor treatments.

Patients with a histopathological diagnosis of any precancerous lesions or non-malignant disease.

Disqualifiers

Patients with metastatic tumors or in the condition with two or more kinds of malignant tumors at the same time

Post-cancer treatment patients.

Trial design

Treatments tested in this trial

  • No Interventions

Treatment groups

600 Participants
are divided into 11 treatment groups

11

Treatment groups

See each treatment group below.

Sponsors and collaborators

Second Affiliated Hospital, School of Medicine, Zhejiang University

Lead sponsor

The First Affiliated Hospital of Nanchang University

Collaborator

Second Affiliated Hospital of Nanchang University

Collaborator

Huashan Hospital

Collaborator