RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorBaylor Research Institute

About this trial

The goal of this pragmatic randomized clinical trial is to determine whether an Epic-based clinician notification increases initiation of guideline-directed cardio-kidney-metabolic (CKM) therapies in adults with type 2 diabetes and confirmed albuminuria.

The main question it aims to answer is:

• Does an Epic clinician notification improve initiation of guideline-directed CKM therapies compared with usual care?

Researchers will compare an Epic in-basket clinician notification strategy with usual care.

In the intervention arm, the treating clinician will receive an Epic notification identifying confirmed albuminuria and potential eligibility for guideline-directed CKM therapies using existing electronic health record (EHR) data. Participants in the usual care arm will receive standard clinical care without notification.

Eligibility criteria

Qualifiers

Adults aged ≥18 years

Diagnosis of type 2 diabetes mellitus

Receiving outpatient care within Baylor Scott & White Health

At least 1 outpatient encounter within the preceding 12 months

Disqualifiers

Type 1 diabetes mellitus

Contraindication or documented intolerance to all eligible guideline-directed CKM therapies

Advanced kidney dysfunction below recommended initiation thresholds for SGLT2i or finerenone

Hyperkalemia or elevated baseline serum potassium precluding safe therapy initiation

Trial design

Treatments tested in this trial

  • Epic-Based Clinician Notification
  • Usual Care

Treatment groups

600 Participants
are divided into 2 treatment groups

Sponsors and collaborators