Regression of Cervical Precancerous Lesions and Associated Risk Factors

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-40
SponsorGeneral University Hospital, Prague

About this trial

The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion of patients who experience the normalization of HPV test and cytology finding among those who were treated conservatively and those who underwent conization; and identify predictive parameters associated with regression. Based on this analysis, a model will be proposed to predict the likelihood of lesion regression.

Eligibility criteria

Qualifiers

squamocolumnar junction fully visualized

bioptically verified CIN 2 or CIN 3

age ≥ 18 years

age ≤ 40 years

Disqualifiers

squamocolumnar junction not fully visualized

suspicion on glandular lesion

suspicion on invasive cancer

personal history of CIN 2, 3 or cerv. cancer

Trial design

Treatments tested in this trial

  • Colposcopy

Treatment groups

300 Participants
are divided into 1 treatment group