Retinal Oxygen Metabolism in Children With Myopia
ConditionMyopia
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age8-13
SponsorMedical University of Vienna
About this trial
The aim of the present study is to gain more information about retinal functional parameters in myopic children in Europe. For this purpose, a prospective case-control study in children aged between 8 and 13 years, as this is the usual age of myopia onset, will be conducted. Forty myopic children will be age- and sex-matched to non-myopic controls. Retinal oxygen extraction will be used as the main outcome parameter, as data from animal and human studies point towards an involvement of hypoxia in the disease process. In addition, other parameters probably linked to myopia will be investigated, such as retinal and choroidal blood flow as well as choroidal and retinal vessel density and anatomical structures such as choroidal and central retinal thickness. Also, questionnaires about lifestyle factors will be completed.
Eligibility criteria
Qualifiers
Children aged between 8 and 13 years (inclusive)
Signed informed consent of child and legal guardian
Normal ophthalmic findings except myopia
Cycloplegic spherical equivalent (SE) refraction ≤ -1.0dpt in both eyes
Disqualifiers
Intake of stimulating beverages containing xanthine derivatives (tea, coffee, cola-like drinks) 12 hours before the study day
Previous eye abnormalities such as cataract, keratopathy, strabismus, amblyopia, ocular inflammation, trauma, or surgery
History of any disease or syndrome associated with severe myopia such as Marfan syndrome, Stickler syndrome, or retinopathy of prematurity
Non-axial cause of myopia
Trial design
Treatments tested in this trial
- Not listed
Trial groups
80 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov