The purpose of this study is to evaluate the safety and efficacy of urinary kallidinogenase treatment in patients with large artery atherosclerotic acute ischemic stroke.
Age ≥18 years old;
Acute anterior circulation large artery atherosclerotic cerebral infarction (according to TOAST classification) within 48h of onset; NIHSS score ≥6, ≤15;
Moderate to severe stenosis or occlusion of offending vessels;
The mRS Score ≤2 before onset;
Transient ischemic attack;
Patients who planned or had received emergency reperfusion therapy (including intravenous thrombolysis and emergency thrombectomy);
Severe disturbance of consciousness:GCS ≤8;
Patients who previously received angiotensin-converting enzyme inhibitor (ACEI) drugs regularly;
Yi Yang
Lead sponsor
The First Hospital of Jilin University
Sponsor institution