Stem Cell Applications in Biliary Atresia Patients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age2-18
SponsorNecmi Kadıoğlu Hospital
About this trial
Recently, mesenchymal stem cell (MSC) transplantation has emerged as a promising treatment for liver cirrhosis in adults. Additionally, bone marrow-derived stem cell transplantation has shown success in treating children with biliary atresia (BA). This study aims to evaluate the efficacy of Umbilical Cord-Derived Mesenchymal Stem Cell (UC-MSC) therapy in BA through a multicentric randomized controlled trial.
Eligibility criteria
Qualifiers
Infants were diagnosed with liver cirrhosis due to biliary atresia following Kasai's operation.
The patients two months old or older and exhibited signs of cirrhosis after the procedure, including hepatomegaly, congestive splenomegaly, elevated liver enzymes, esophageal varices (confirmed by endoscopy), and cirrhosis (confirmed by liver biopsy).
Disqualifiers
Epilepsy
Neurological disorders
Coagulation disorders
Diabetes
Trial design
Treatments tested in this trial
- Stem Cell
- Control
Treatment groups
64 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov