SUCCESS Score Validation in Fuchs Dystrophy
ConditionFuchs Endothelial Corneal Dystrophy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40+
SponsorInstituto Ramón y Cajal de Investigación Sanitaria
About this trial
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal dystrophy (FECD). The model's performance and clinical utility are assessed using discrimination, calibration, and reclassification metrics.
Eligibility criteria
Qualifiers
Adults aged ≥40 years.
Clinical diagnosis of Fuchs endothelial corneal dystrophy (FECD) grade ≥2 on the modified Krachmer scale.
Presence of visually significant cataract requiring phacoemulsification surgery.
Ability to provide informed consent and comply with study procedures.
Disqualifiers
Epithelial or stromal edema precluding reliable corneal imaging.
Previous ocular surgery (including corneal or intraocular procedures).
Corneal trauma, infection, or inflammation affecting endothelial integrity.
Coexisting ocular pathologies that could confound postoperative assessment (e.g., advanced glaucoma, macular degeneration).
Trial design
Treatments tested in this trial
- Phacoemulsification Cataract Surgery
Treatment groups
250 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov