This study intends to implement esketamine-assisted anesthesia in patients undergoing non-inflatable transoral endoscopic thyroidectomy through a prospective randomized controlled trial, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.
Patients scheduled for endotracheal intubation-free thyroid surgery under oral endoscopy
ASA class I-II
Voluntarily participate in the study and sign the informed consent form
Body Mass Index > 30 kg/m²
Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure >180/100 mmHg)
Hepatic or renal dysfunction
History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations