The Effect of Exercise on the Brain in Type 2 Diabetes
ConditionType 2 Diabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-75
SponsorHasselt University
About this trial
The goal of this clinical trial is to learn if exercise training of high or moderate intensity is most optimal to improve brain health and prevent neurodegeneration in type 2 diabetes patients. The main question it aims to answer is:
What is the effect of exercise training of high vs. moderate intensity on brain metabolism, brain perfusion, and cognition in type 2 diabetes?
Researchers will compare the exercise training groups to a control group without exercise training to determine the effect of exercise training on the brain in type 2 diabetes.
Participants will exercise for 6 months, 3 times per week. Before and after these 6 months, they will undergo:
* a brain MRI scan * cognitive tests * blood sampling
Eligibility criteria
Qualifiers
type 2 diabetes
no insulin therapy
30-75 years old
physically inactive
Disqualifiers
MRI contraindications
psychological disorders
exogenous insulin therapy
history of coma, transient ischemic attack, head trauma, brain tumor, stroke, epilepsy, and other central nervous system diseases that could cause dementia or presence of dementia before T2DM
Trial design
Treatments tested in this trial
- Exercise intervention
Treatment groups
75 Participants
are divided into 3 treatment groupsSponsors and collaborators
Hasselt University
Lead sponsor
Universitaire Ziekenhuizen KU Leuven
Collaborator
Jessa Hospital
Collaborator
Research Foundation Flanders
Collaborator
Source ClinicalTrials.gov