The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45-75
SponsorIstanbul University
About this trial
In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee osteoarthritis will be determined and compared with the placebo group. In addition, the effects of HA injection on pain, functional status and quality of life will be evaluated and these effects will be related to changes in TNF-alpha and IL-1-beta.
Eligibility criteria
Qualifiers
Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria
Knee pain for more than 3 months
Presence of knee pain resistant to conservative treatment for at least 3 months
To be between the ages of 45-75
Disqualifiers
Patients with KL stage 1 and 4 OA
Systematic diseases (severe cardiovascular disease, severe renal failure, severe hepatic failure, uncontrolled diabetes, cancer, immunosuppression, haematological diseases, systemic bone diseases)
Bleeding tendency (acquired or inherited) [lNR>2 in a patient on Coumadin],
Infection (systemic or local)
Trial design
Treatments tested in this trial
- Hyaluronic Acid injections
- Saline -- placebo comparator
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Istanbul University
Lead sponsor
Istanbul University Research Fund
Collaborator
Source ClinicalTrials.gov