The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis

ConditionMeniscus Tear
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-55
SponsorJordan University of Science and Technology

About this trial

This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.

Eligibility criteria

Qualifiers

Are between 35 and 55 years of age.

Presence of medial knee pain.

Medial joint line tenderness.

Pain and limited motion when attempting to perform a full squat and

Disqualifiers

Radiographic evidence of OA (K-L grade 2 or above).

A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus).

A meniscus injury that requires meniscectomy (locked knee).

Prior or current ligament injury or surgery of the involved knee.

Trial design

Treatments tested in this trial

  • Progressive Resistance Exercise (PRE)
  • Aerobic Exercise
  • Control

Treatment groups

50 Participants
are divided into 3 treatment groups