The Effects of Endotracheal Suctioning on Pain and Serum Markers

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorLoma Linda University

About this trial

The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.

The main questions this study aims to answer are:

Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.

Participants will:

Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.

Provide demographic information (like age, gender, and diagnosis) from medical records.

This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.

Eligibility criteria

Qualifiers

Adults (aged 18 years and older)

Current diagnosis of flu, pneumonia, COVID, or sepsis

Intubated and receiving mechanical ventilation.

Have arterial lines placed

Disqualifiers

Patients receiving neuromuscular blocking agents

Contraindications for blood draws (hemoglobin levels below 8.0 g/dL; Jehovah's Witness)

Trial design

Treatments tested in this trial

  • endotracheal tube suctioning

Treatment groups

110 Participants
are divided into 2 treatment groups

Sponsors and collaborators