The Effects of Exogenous Ketones on Cognitive Function
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-55
SponsorUniversity of Alabama at Birmingham
About this trial
The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean, sedentary individuals; and (3) lean individuals who engage in regular physical activity (e.g., collegiate or amateur athletes). The main questions it aims to answer are to:
* Assess the effects of acute KME supplementation versus placebo on cognitive, sensorimotor, and functional outcomes within groups. * Compare cognitive performance across the three groups.
The primary outcome is cognitive performance assessed using the NIH Toolbox Cognition Battery. Secondary Outcomes include sensorimotor performance, measured using the Senaptec Sensory System, and driving performance, assessed with a driving simulator.
Eligibility criteria
Qualifiers
Age 19-55 years
BMI 30-40 (obese group) or 18-25 (lean and athlete groups)
Sedentary status (<2 hrs/week of structured physical activity) for obese and lean groups
Active athlete status (≥5 days/week of structured activity) for athlete group
Disqualifiers
Diagnosed neurological conditions (e.g., Parkinson's disease, multiple sclerosis, schizophrenia, muscular dystrophy, stroke, cerebral palsy)
History of seizures
Use of medications for diabetes, mood disorders, or attention disorders
Pregnant or breastfeeding
Trial design
Treatments tested in this trial
- Ketone Monoester (KE)
- Placebo
Treatment groups
45 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov