The European NAFLD Registry is a prospectively recruited, observational study supporting the study of the clinical phenotype, natural history, disease outcomes and pathophysiology of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. The ultimate goals are to better understand the drivers of interpatient variation in disease pathophysiology and severity and to utilise this information to develop and validate biomarkers that, singly or in combination, enable detection and monitoring of disease progression and/or from NAFL through NASH to fibrosis and cirrhosis.
Age ≥18 years.
Patient with historical liver biopsy providing histological evidence of NAFLD or,
Patient undergoing liver biopsy for suspected NAFLD with biochemical and/or radiological findings consistent with NAFLD or,
Increased waist circumference by ethnically adjusted criteria (e.g. Europid male/female ≥94cm/80cm) or overweight/obese (BMI ≥25);
Refusal or inability (lack of capacity) to give informed consent.
Average alcohol ingestion greater than approximately 21/14 units/week (males/females) in preceding 6 months or history of sustained excessive consumption of alcohol in past 5 years.
History or presence of Type 1 diabetes mellitus.
Presence of any other form of chronic liver disease except NAFLD.
Newcastle University
Lead sponsor
Newcastle-upon-Tyne Hospitals NHS Trust
Collaborator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborator
Institute of Cardiometabolism and Nutrition, France
Collaborator
University of Cambridge
Collaborator
Örebro University, Sweden
Collaborator
University of Bern
Collaborator
University of Oxford
Collaborator
University of Turin, Italy
Collaborator
Angers University
Collaborator
University Hospital, Antwerp
Collaborator
Linkoeping University
Collaborator
University of Helsinki
Collaborator
UMC Utrecht
Collaborator
National and Kapodistrian University of Athens
Collaborator
University of Lisbon
Collaborator
University of Milan
Collaborator
University of Palermo
Collaborator
Catholic University of the Sacred Heart
Collaborator
Wuerzburg University Hospital
Collaborator
RWTH Aachen University
Collaborator
University of Nottingham
Collaborator
Medical University of Vienna
Collaborator
University of Birmingham
Collaborator
University of Florence
Collaborator
Assistance Publique - Hôpitaux de Paris
Collaborator
University Medical Center Mainz
Collaborator