AI diagnostic systems show great promise for improving lung cancer screening in community healthcare settings. While not originally designed for primary care, these tools demonstrate capabilities in nodule detection and workflow optimization. However, their effectiveness in resource-limited community centers requires thorough evaluation.
This RCT compares AI-assisted versus manual CT interpretation across community health centers. Expert radiologists will establish reference standards, while an independent committee blindly evaluates cases from both groups. The study assesses diagnostic accuracy, operational efficiency, and cost-effectiveness, with blinded analysts resolving discrepancies through consensus to ensure reliable results.
Aged 45-74 years
Permanent resident of participating study communities
No prior history of lung cancer and no lung cancer screening within the past 3 months
Able to comprehend and voluntarily sign informed consent, with willingness to participate in long-term follow-up
Individuals with a confirmed diagnosis of lung cancer
Those with severe comorbidities contraindicating CT imaging
Inability to understand study protocols or provide informed consent due to cognitive impairment
Concurrent participation in other clinical trials that may interfere with study outcomes