The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome

ConditionsEnergy Expenditure Metabolic Syndrome Anthropometry Body Composition Glycemia Lipaemia Metabolomics Blood Pressure

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorKU Leuven

About this trial

During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.

Eligibility criteria

Qualifiers

male and female participants

central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)

Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)

Triglyceride concentration ≥ 150 mg/dl

Disqualifiers

gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea

history of abdominal surgery, except for appendectomy

Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids

Use of antibiotics 3 months prior to the start or during the study

Trial design

Treatments tested in this trial

with short-chain fatty acids enriched drink
unenriched oat drink

Treatment groups

50 Participants

are divided into 2 treatment groups

Sponsors and collaborators

KU Leuven

Lead sponsor

Source ClinicalTrials.gov