The Parkinson's Disease Case-Control Study
ConditionParkinson Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-75
SponsorWestlake University
About this trial
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China. This study aims to systematically investigate the differences in intestinal fungi between patients and healthy volunteers, find the key strains, and explore the molecular mechanism of Parkinson's disease with multi-omics data. Another aim of this study is to explore the association between intestinal fungi and brain structure and function from the perspective of the gut-brain axis by combining brain image data.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Men or women aged 50 to 75 years.
Clinical diagnosis of Parkinson's disease (based on MDS Parkinson's disease diagnostic criteria)
The patient must have at least two of the following symptoms: static tremor, bradykinesia, stiffness (which must include at least static tremor or bradykinesia); Or have asymmetrical resting tremors or asymmetrical bradykinesia.
Able to provide informed consent.
Disqualifiers
Atypical or secondary parkinsonism due to medications (e.g., metoclopramide, flunarizine, antipsychotics) or metabolic diseases (e.g., Wilson's disease), encephalitis, or degenerative diseases (e.g., progressive supranuclear palsy).
The presence of clinically diagnosed dementia as determined by the investigator.
Previous MRI scans showed clinically significant neurological disorders (as judged by the investigator).
Serious illness (e.g., heart failure or malignancy).
Trial population
All the participants should be residents living in Hangzhou, China
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Gut microbiome profiling
The microbiome profile is analyzed based on stool samples.
Time frame
At enrollmentSecondary outcomes
1
Fecal and serum metabolomics profiling
Metabolomics profiles are analyzed based on blood samples and stool samples.
Time frame
At enrollment2
Blood and urine proteomics profiling
Proteomics profiles are analyzed based on blood samples and urine samples.
Time frame
At enrollment3
Brain imaging features
MRI scans are used to extract brain imaging features.
Time frame
At enrollmentSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov