The PRE-VAIL Study

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe First Hospital of Jilin University

About this trial

During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe mechanically ventilated acute respiratory distress syndrome (ARDS).

The experimental group had the enteral nutrition dose reduced before the prone position, while the control group did not have the enteral nutrition dose reduced

Eligibility criteria

Qualifiers

Age ≥18 years old

Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)

Meet the diagnostic criteria for moderate/severe ARDS (even after optimizing the ventilation Settings, the oxygenation index is still < 150mmHg and PEEP is still ≥5 cm H2O)

It is expected to stay in the ICU for more than 48 hours

Disqualifiers

There are contraindications for the prone position

There are contraindications for EN, preventing the initiation of early EN (≤48 hours)

Expected to die within 48 hours

Pregnancy

Trial design

Treatments tested in this trial

  • Enteral nutrition is reduced before the prone position

Treatment groups

259 Participants
are divided into 2 treatment groups