Based on recent studies it is hypothesized that microplastics and nanoplastics (MNPs) are present in human's ileum, colon, and rectum and that their presence may have a correlation with Inflammatory Bowel Disease (IBD).
This study is a cross-sectional, single-center, non-profit observational study. The main objectives are to define in vitro the presence of MNPs in the humans ileum, colon, and rectum and to evaluate if there is a correlation between this presence and IBD. In vitro metabolomics and proteomics analyses of the study sample and the assessment of participants' daily plastic exposure are considered exploratory objectives. For this purpose, a total of 102 patients undergoing a surgery where intestinal resection is included, will be enrolled.
Patients who will undergo any type of bowel surgery due to any type of clinical condition, as established by normal clinical practice, where colon, ileum and/or rectum resection is involved.
Patients aged ≥ 18 years.
Patients who have read, understood, accepted, and signed the informed consent to the study.
Female patients within and outside of childbearing age (breastfeeding women can be included in the study)
Patients aged < 18 years.
Pregnant women.
Patients who have not accepted informed consent.
Pierpaolo Sileri
Lead sponsor
IRCCS Ospedale San Raffaele
Sponsor institution