To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorFujian University of Traditional Chinese Medicine

About this trial

Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.

Eligibility criteria

Qualifiers

Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;

Oral dysphagia caused by stroke;

FOIS level ≤ 5; WST level ≥3;

Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;

Disqualifiers

Dysphagia not caused by stroke or non-oral dysphagia;

History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases;

Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression;

Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses;

Trial design

Treatments tested in this trial

  • Swallowing function test

Treatment groups

72 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Fujian University of Traditional Chinese Medicine

Lead sponsor

Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science

Collaborator