Transcranial Magnetic Stimulation in Veterans With PTSD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-70
SponsorWhite River Junction Veterans Affairs Medical Center
About this trial
With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.
Eligibility criteria
Qualifiers
Age between 19 and 70
Eligible for VA healthcare
Moderate to severe PTSD as determined by a total score of at least 25 on the CAPS within 7 days of randomization.
Agree to have CAPS audio recorded.
Disqualifiers
Pregnant or lactating woman.
MRI is contraindicated
Current use of clozapine (any dose) or bupropion (more than 300mg per day).
Cardiac pacemaker or implantable defibrillator.
Trial design
Treatments tested in this trial
- Transcranial Magnetic Stimulation
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov