Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity of Maryland, Baltimore

About this trial

Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward.

The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.

Eligibility criteria

Qualifiers

symptomatic tracheal stenosis

idiopathic subglottic stenosis

iatrogenic tracheal stenosis from intubation or tracheostomy

Disqualifiers

positive ANA or ANCA

tracheal stenosis from infection, i.e. TB

tracheal stenosis with cartilage fracture

tracheal stenosis with malacia

Trial design

Treatments tested in this trial

  • Bronchoscopy, carbon dioxide (CO2) laser wedge resection
  • Radial incision with dilation

Treatment groups

40 Participants
are divided into 2 treatment groups