Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorStony Brook University

About this trial

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.

Eligibility criteria

Qualifiers

None

Disqualifiers

Bipolar disorder diagnosis: Patients must have a Diagnostic Statistical Manual (DSM)-V diagnosis of bipolar disorder on the Structured Clinical Interview for DSM (SCID)

Bipolar disorder symptoms: Patients must be stable and euthymic at time of consent and testing, documented by no hospitalizations in the prior 4 weeks

Age: between 18-45 yrs for patients with bipolar disorder and age-matched controls

Weight does not exceed 350lbs.

Trial design

Treatments tested in this trial

  • Glucose
  • Ketones

Treatment groups

100 Participants
are divided into 1 treatment group

Sponsors and collaborators

Stony Brook University

Lead sponsor

Massachusetts General Hospital

Collaborator

Mclean Hospital

Collaborator