Walking for Hypothyroidism Trial (WHT)
ConditionHypothyroidism
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age35-55
SponsorUniversity of Karachi
About this trial
Women with hypothyroidism often report persistent fatigue, weight gain, autonomic dysregulation, and stress despite stable levothyroxine therapy. This single-center, parallel-group RCT will test whether a structured, supervised 12-week walking program improves basal metabolic rate (BMR) and psychophysiological outcomes compared with usual activity. One hundred twenty women aged 35-55 with stable primary hypothyroidism will be randomized 1:1 to intervention or control.
Eligibility criteria
Qualifiers
Female, aged 35-55 years
Primary hypothyroidism with documented prior TSH >4.5 mIU/L
Stable levothyroxine dose for at least 6 months
Sedentary lifestyle (<150 minutes of moderate-vigorous activity per week)
Disqualifiers
Pregnant or lactating, or planning pregnancy during the study period
Use of beta-blockers, systemic corticosteroids, or medications significantly affecting heart rate, HRV, or metabolism
Uncontrolled hypertension, insulin-dependent diabetes, symptomatic cardiovascular disease, or orthopedic conditions limiting walking
Major psychiatric hospitalization in the past 12 months
Trial design
Treatments tested in this trial
- Supervised Walking Program
Treatment groups
120 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Karachi
Lead sponsor
Advanced Education & Research Center
Collaborator
Source ClinicalTrials.gov