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Westlake Longevity Cohort

ConditionAging
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorWestlake University

About this trial

The Westlake Longevity Cohort (We-Longevity) is a prospective cohort study among centenarians, nonagenarians and senior citizens living in Lishui, China. The primary aim of this cohort is to characterize the multi-omics molecular characteristics of healthy longevity and their dynamic trajectories. The second aim is to culture the gut microbiota of these elderly people through culturomics. The third aim of We-Longevity is to investigate the association of dietary and lifestyle with the multi-omics molecular characteristics of healthy longevity, and to facilitate the development of personalized nutritional/lifestyle recommendation for the public.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participants live in Lishui, China.

Participants intend to remain in Lishui for ≥3 years.

Disqualifiers

Participants with infectious diseases.

Trial population

All the participants should be Chinese residents, regardless of the ethics.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Physical frailty

Physical frailty will be evaluated by using Fried's criteria.

Time frame
36 months
2

Gut microbiome

Fecal microbiome will be analyzed by 16S/ITS rRNA gene sequencing and metagenome sequencing. Furthermore, fecal microbiota will be cultured, picked and identified.

Time frame
36 months

Secondary outcomes

1

Cognitive function

Cognitive function will be evaluated by using Mini-Mental State Examination (MMSE).

Time frame
36 months
2

Blood biochemical parameters

Blood biochemical parameters (e.g., glucose and lipids) will be analyzed by an automated biochemical analyzer.

Time frame
36 months
3

Metabolomics profiling

Blood and fecal metabolomics will be analyzed by LC-MS/MS.

Time frame
36 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Westlake University

Lead sponsor

Source ClinicalTrials.gov
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