What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care unit (ICU), and to identify whether AKI is an independent predictor of difficult, failed or complicated or weaning.
Eligibility criteria
Qualifiers
• Age ≥ 18 years of either sex.
Admission to the ICU and receiving invasive mechanical ventilation via endotracheal tube.
Expected duration of mechanical ventilation ≥ 24 hours.
Hemodynamically stable or stabilized at the time of first spontaneous breathing trial (SBT) according to unit protocol (e.g., mean arterial pressure ≥ 65 mmHg with or without low dose vasopressors).
Disqualifiers
Pre existing end stage renal disease on chronic dialysis (hemodialysis or peritoneal dialysis).
Known advanced chronic kidney disease (e.g., baseline estimated GFR < 30 mL/min/1.73 m²) if baseline creatinine is available.
Previous tracheostomy before current ICU admission.
Neuromuscular diseases or spinal cord injury causing chronic ventilatory dependence.
Trial design
Treatments tested in this trial
- Acute Kidney Injury (AKI) Exposure
Treatment groups
No treatment groups listed
Locations
Sponsors and collaborators
Source ClinicalTrials.gov