Cervical Radiculopathy

27

Review clinical trials related to Cervical Radiculopathy. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Assessment of Upper Extremity Proprioception in Patients With Cervical Radiculopathy

There is no study in the current literature that systematically investigates the extent of upper-extremity proprioceptive impairment in patients with radicular neuropathic symptoms secondary to cervical disc herniation, nor its association with clinical findings. Although existing reviews emphasize proprioceptive deficits in populations with neck pain or cervical spondylosis, no studies specifically address the subgroup of cervical disc-related radiculopathy. This gap in knowledge hinders the integration of proprioceptive assessments with upper-extremity functional outcome measures in diagnostic and rehabilitative processes, suggesting a need for more specific data to guide sensory-motor training approaches. The primary aim of the present study is to assess upper-extremity proprioception in patients with cervical radiculopathy by comparing them with a healthy control group. The secondary aim is to examine the relationship between upper-extremity proprioception and clinical outcomes, including parameters such as pain and functional status.

Participants needed: 58
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Marmara UniversityUpdated: Jun 4, 2026Locations: 1
Eligibility criteria

Being between 18 and 65 years of age [+2]

History of cervical physical therapy within the past year [+12]

Status: Recruiting

Effects of DRT on Neck Pain, ROM, and Chest Expansion in Patients With CR

This randomized controlled trial aims to determine the effects of the diaphragmatic release technique on neck pain, cervical range of motion, and chest expansion in patients with cervical radiculopathy. Participants will be randomized to either the baseline treatment or the experimental group for five weeks.

Participants needed: 40
Trial details
Age: 35-55Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Jun 5, 2026Locations: 1
Eligibility criteria

Presence of unilateral neck pain and paresthesia symptoms for about 2 months [+5]

Any tumor [+6]

Status: Recruiting

Ultrasound Guided Transcutaneous Pulsed Radiofrequency for Cervical Radiculopathy

Cervical radiculopathy (CR) is a painful condition caused by irritation of the cervical nerve roots, often leading to neck, shoulder, and arm pain, sometimes with numbness or weakness. These symptoms can reduce quality of life and place a burden on healthcare systems. Current treatments, such as physical therapy, cervical traction, and medication, are often not fully effective. Pulsed radiofrequency (PRF) has shown benefits for nerve-related pain, but because it requires an invasive procedure, its use is limited. Transcutaneous pulsed radiofrequency (TCPRF) is a non-invasive version of PRF. It has shown promising results in animal studies and in clinical research for knee and shoulder conditions, but has not been tested for CR. Recent improvements in ultrasound allow more precise targeting of cervical nerve roots, making ultrasound-guided TCPRF a potentially safe and accessible treatment option. This pilot study will evaluate the efficacy and safety of ultrasound-guided TCPRF in patients with CR compared to a sham treatment. A total of 32 participants with CR lasting more than six weeks will be randomly assigned to either TCPRF or sham treatment. Both groups will receive 12 treatment sessions over four weeks, combined with a standard rehabilitation program. The main outcome is pain intensity measured by the Numeric Rating Scale (NRS). Secondary outcomes include neck-related disability, medication use, and any side effects.

Participants needed: 32
Trial details
Age: 20-75Biological sex: AllType: InterventionalSponsor: Shin Kong Wu Ho-Su Memorial HospitalUpdated: May 13, 2026Locations: 1
Eligibility criteria

Age between 20 and 75 years old. [+7]

History of cervical spine surgery. [+10]

Status: Not yet recruiting

Transcutaneous Auricular Vagus Nerve Stimulation Combined With Cervical Epidural Injection for Cervical Radiculopathy

This is a prospective, randomized, double-blinded, sham-controlled trial conducted to investigate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) combined with cervical epidural injection in the treatment of cervical radiculopathy. A total of 80 subjects will be enrolled and randomly assigned (1:1) to either the experimental group or the control group. The primary outcome measure is the proportion of subjects with a ≥50% reduction in the Numerical Rating Scale (NRS) pain score at discharge. Secondary outcomes include pain intensity, pain interference, psychological status, sleep quality, physical disability, and autonomic function measurements. Adverse events will be monitored throughout the study.

Participants needed: 80
Trial details
Age: 18-85Biological sex: AllType: InterventionalSponsor: Second Affiliated Hospital, School of Medicine, Zhejiang UniversityUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

Age between 18 and 85 years old. [+5]

Arrhythmia requiring treatment, severe bradycardia, or postural orthostatic tach... [+4]

Status: Not yet recruiting

Transcutaneous Electrical Nerve Stimulation Versus Repetitive Transcranial Magnetic Stimulation on Pain and Functional Outcome in Cervical Radiculopathy

this study will be conducted to compare between transcutaneous electrical nerve stimulation versus repetitive transcranial magnetic stimulation on pain and functional outcome in cervical radiculopathy

Participants needed: 50
Trial details
Age: 30-45Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Apr 29, 2026
Eligibility criteria

patients will be from both sexes, aged between (30 to 45) years [+4]

Patients with a history of injury to the cervical spine. [+6]

Status: Recruiting

Cervical Radiculopathy Imaging Using MRN With Electrodiagnostic Correlation

This project will study patients with cervical radiculopathy. We will evaluate the combined diagnostic and prognostic value of magnetic resonance neurography (MRN), electrodiagnostic (EDX) studies, and historical and physical clinical elements. Specifically, this project will explore whether these data individually or in combination correlate with response to procedural and non-procedural treatment.

Participants needed: 20
Trial details
Age: 18-60Biological sex: AllType: ObservationalSponsor: Hospital for Special Surgery, New YorkUpdated: Apr 27, 2026Locations: 1
Eligibility criteria

Patients presenting with symptoms compatible with acute or subacute unilateral (... [+4]

Prior cervical surgery or instrumentation [+5]

Status: Recruiting

Home-Based Exercise After Cervical Epidural Steroid Injection for Cervical Radiculopathy

Cervical radiculopathy is a common cause of neck and arm pain resulting from compression or inflammation of a cervical nerve root. Cervical epidural steroid injection is frequently used to reduce pain and improve function in patients who do not respond to conservative treatment. However, long-term functional recovery may require additional rehabilitation strategies. This randomized controlled trial aims to investigate whether adding a standardized home-based exercise program after cervical interlaminar epidural steroid injection improves pain, disability, sleep quality, and quality of life in patients with chronic cervical radiculopathy. Participants will be randomly assigned to receive either injection alone or injection followed by an eight-week home-based exercise program.

Participants needed: 60
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: Necmettin Erbakan UniversityUpdated: Apr 2, 2026Locations: 1
Eligibility criteria

Age between 18 and 70 years. [+5]

Clinical signs of cervical myelopathy or progressive neurological deficit. [+6]

Status: Recruiting

Mulligan Mobilization & Stretching Effects of Cervical

1. To evaluate the effectiveness of mulligan mobilization and stretching exercises in reducing pain in individuals with cervical radiculopathy. 2. To evaluate the effectiveness of mulligan mobilization and stretching exercises in reducing disability in individuals with cervical radiculopathy. 3. To evaluate the effectiveness of mulligan mobilization and stretching exercises at improving ranges in individuals with cervical radiculopathy.

Participants needed: 30
Trial details
Age: 20-50Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Feb 25, 2026Locations: 1
Eligibility criteria

Participants falling in this category would be recruited into the study. [+5]

Participant failing to fall in this category would be excluded of the study. [+7]

Status: Not yet recruiting

Nerve Gliding Exercises in Cervical Radiculopathy

The aim of this study is to investigate the effect of nerve gliding exercises on pain, cervical range of motion, joint position sense, grip strength, functional status and quality of life in individuals with cervical radiculopathy.

Participants needed: 28
Trial details
Age: 18-55Biological sex: AllType: InterventionalSponsor: Zonguldak Bulent Ecevit UniversityUpdated: Feb 24, 2026Locations: 1
Eligibility criteria

Have been diagnosed with cervical radiculopathy by a specialist physician [+2]

Predominance of primary peripheral entrapment neuropathy (carpal/cubital/radial... [+7]

Status: Recruiting

Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be age-matched and randomly assigned to either implant with informed consent. All subjects will undergo a variety of assessments that evaluate neck disability, quality of life, pain, physiological outcome (radiographic assessments), and neck range-of motion before and after their procedure. One baseline testing will be conducted along with three post-operation visits (three months, six months, and one year) in accordance to standard follow-up procedure. Thus, the duration of participation in the study will be approximately one and a half years.

Participants needed: 20
Trial details
Age: 18-60Biological sex: AllType: ObservationalSponsor: University of California, Los AngelesUpdated: Feb 13, 2026Locations: 1
Eligibility criteria

Patient is skeletally mature and between 18 to 60 years of age [+4]

Patient has had prior cervical spine surgery [+5]

Status: Not yet recruiting

Effect of Cervical Traction With Neural Mobilization on Nerve Root Functions in Cervical Radiculopathy Patients

This study will be conducted to examine 1. The efficacy of mechanical traction from decompression angles combined with neural mobilization on the H reflex of flexor carpi radialis. 2. The efficacy of mechanical traction from decompression angles combined with neural mobilization on ultrasonography changes. 3. The efficacy of mechanical traction from decompression angles with neural mobilization has a Numeric Pain Rating Scale. 4. The efficacy of mechanical traction from decompression angles combined with neural mobilization on Neck Disability Index.

Participants needed: 45
Trial details
Age: 30-45Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jan 26, 2026Locations: 1
Eligibility criteria

The patient's age will be ranged from 30 to 45 years old for both genders. [+3]

History of surgical procedures for pathologies giving rise to neck pain or carpa... [+7]

Status: Not yet recruiting

Combination of Kinesio Tape and Proprioceptive Neck Exercises on Proprioception in Patients With Cervical Radiculopathy

This study is conducted to investigate: 1. The efficiency of combination of KT and proprioceptive exercises on neck proprioception in patients with CR. 2. The efficiency of combination of KT and proprioceptive exercises on neck pain, neck function and neuropathic pain in patients with CR.

Participants needed: 60
Trial details
Age: 35-50Biological sex: AllType: InterventionalSponsor: Fadia Ahmed FawzyUpdated: Jan 12, 2026
Eligibility criteria

Age from 35-50years (Rafiq et al. 2022). [+8]

History of surgical procedures for pathologies giving rise to neck pain or CTS (... [+7]

Status: Recruiting

Investigation of the Effects of Interlaminar Epidural Steroid Injection on Upper Extremity Proprioception in Patients With Chronic Cervical Radiculopathy

Cervical radiculopathy is a common condition caused by irritation or compression of cervical nerve roots, often leading to unilateral neuropathic pain and functional impairment. Proprioceptive deficits in the upper extremity have been demonstrated in various cervical spine disorders; however, the effect of interlaminar epidural steroid injection (ILESI) on upper extremity proprioception in patients with chronic cervical radiculopathy has not been previously examined. This prospective interventional study aims to evaluate changes in upper extremity proprioception following unilateral ILESI in patients with cervical disc herniation-related chronic radiculopathy. A secondary aim is to investigate the relationship between proprioceptive changes and clinical outcomes such as pain, neuropathic pain, disability, grip strength, and quality of life.

Participants needed: 46
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Marmara UniversityUpdated: Jan 2, 2026Locations: 1
Eligibility criteria

Female or male, 18-65 years of age [+5]

Cervical physical therapy or cervical spinal injection performed within the past... [+20]

Status: Not yet recruiting

Correlation Between Cervical Deep Flexors Endurance and Proprioception Function in Cervical Radiculopathy

In cervical radiculopathy, reduced endurance of the deep cervical flexor muscles is associated with impaired cervical proprioception. This relationship reflects altered sensorimotor control due to muscle dysfunction and neural compromise, emphasizing the need for deep flexor endurance training in rehabilitation.

Participants needed: 80
Trial details
Age: 30-45Biological sex: AllType: ObservationalSponsor: Delta University for Science and TechnologyUpdated: Jan 6, 2026
Eligibility criteria

Adults diagnosed with cervical radiculopathy based on clinical examination (± im...

History of cervical spine surgery or acute cervical trauma.

Status: Not yet recruiting

Gait Asymmetry And Its Relationship With Neck Pain And Muscles Strength In Patients With Cervical Radiculopathy

This study will be conducted to: * Investigate the relationship between neck pain severity and bilateral gait symmetry in patients with cervical radiculopathy. * Investigate the relationship between deep neck flexors strength and gait symmetry in patients with cervical radiculopathy. * Investigate the relationship between upper limb muscles strength and bilateral gait symmetry in patients with cervical radiculopathy. * Determine factors predicting bilateral gait asymmetry in patients with cervical radiculopathy.

Participants needed: 61
Trial details
Age: 40-50Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Jan 8, 2026Locations: 1
Eligibility criteria

Patients with unilateral cervical radiculopathy at level of C5-C6 and C6-C7 conf... [+5]

Bilateral cervical radiculopathy. [+7]

Status: Not yet recruiting

Effect of TECAR on Cervical Radiculopathy

Cervical radiculopathy is characterized by pain, sensory disturbances, and impaired neuromuscular control due to nerve root compression. Proprioception dysfunction is often an overlooked component of this condition and can affect balance, posture, and motor control. TECAR (Transfer of Energy Capacitive and Resistive) therapy is a form of deep heat electrotherapy known to improve tissue perfusion and neuromuscular function. Although TECAR is widely used for pain relief and mobility, its role in improving proprioception remains under-investigated, especially in cervical conditions. This study aims to bridge this gap by assessing proprioceptive outcomes in patients with cervical radiculopathy receiving TECAR therapy.

Participants needed: 80
Trial details
Age: 30-45Biological sex: AllType: InterventionalSponsor: Delta University for Science and TechnologyUpdated: Dec 18, 2025Locations: 1
Eligibility criteria

• Diagnosed cervical radiculopathy confirmed by clinical and radiological findin... [+2]

• Cervical fracture or surgery [+3]

Status: Not yet recruiting

Relationship Between Craniovertebral Angle, Lumbar Proprioception, and Trunk Muscle Strength in Cervical Radiculopathy

The study aimed to * Investigate the relation of cranio-vertebral angle with lumbar proprioception in patients with cervical radiculopathy. * Investigate the relation of cranio-vertebral angle with trunk muscles strength in patients with cervical radiculopathy. Cervical radiculopathy is a condition that causes neck pain radiating to the arm due to nerve root compression. The study seeks to explore whether posture and trunk control are affected in these patients. Participants will be assessed for craniovertebral angle, lumbar proprioception, and trunk muscle strength using standardized physical therapy evaluation methods. The findings may help in understanding postural and neuromuscular changes associated with cervical radiculopathy and improve rehabilitation programs

Participants needed: 64
Trial details
Age: 30-55Biological sex: AllType: ObservationalSponsor: Basma Ashraf Ali MohamedUpdated: Nov 20, 2025Locations: 1
Eligibility criteria

Patients with cervical radiculopathy with ≥3 months history of neck pain radiati... [+3]

Cervical myelopathy [+14]

Status: Not yet recruiting

Contralateral Neural Tissue Mobilization for Cervical Radiculopathy

Cervical radiculopathy (CR) is a common form of peripheral neuropathic pain characterized by neck and upper extremity symptoms in a dermatomal distribution. Neural tissue mobilization (NTM) is an intervention shown to provide benefit for neuropathic pain presentations; however, some patients are unable to tolerate direct treatment of the symptomatic limb due to allodynia, hyperalgesia, or fear of movement. Early evidence from lower-extremity research suggests that contralateral NTM may produce therapeutic effects similar to ipsilateral treatment, but this approach has not been investigated in individuals with upper-extremity symptoms. This exploratory case series aims to examine the immediate effects of contralateral NTM in adults presenting to outpatient physical therapy with CR. Participants will undergo pre- and post-treatment assessments of pain intensity, disability, fear-avoidance beliefs, pain distribution, and neurodynamic mechanosensitivity. Findings will provide preliminary evidence regarding whether contralateral NTM may serve as a viable treatment option when direct symptomatic limb treatment is not tolerated.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Evidence In MotionUpdated: Nov 25, 2025
Eligibility criteria

Age 18 years or older Presence of unilateral upper-extremity pain in a dermatoma... [+3]

Bilateral upper-extremity pain [+3]

Status: Recruiting

Myo-Electrical and Nerve Root Function Response to Focused Extracorpeal Shock Wave in Cervical Radiculopathy

BACKGROUND: Upper limb nerve root dysfunction with increased active myofascial trigger point in upper trapezius is common problem in patients with cervical radiculopathy. The purpose of this study was to evaluate the effect of Extracorpeal shock wave on the myo-electric and nerve function responses in patients with cervical radiculopathy.

Participants needed: 80
Trial details
Age: 36-46Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Oct 3, 2025Locations: 1
Eligibility criteria

All patients suffer from unilateral discogenic cervical radiculopathy of lower c... [+4]

Posterior osteophytes [+7]

Status: Not yet recruiting

Median Nerve Flossing Technique in Patients With Cervical Radiculopathy

Cervical radiculopathy is a condition of cervical spinal nerve roots which occurs as a result of compression and inflammatory pathology from a space occupying lesion. Nerve flossing technique is a quick mobilization of the strained nerves which will reduce pain .This study aim to determine the effects of nerve flossing technique on pain, range of motion and disability in patients with cervical radiculopathy.

Participants needed: 38
Trial details
Age: 30-50Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Jul 14, 2025Locations: 1
Eligibility criteria

Participants with 30 to 50 years of age group were taken in this study (Gore et... [+3]

Systematic disorders affecting musculoskeletal disorders e.g. Ankylosing spondyl... [+2]

Status: Recruiting

Effect of Kinetic Control Retraining on Neck Proprioception and Functional Outcome in Patients With Cervical Radiculopathy

The aim of this study is to investigate the effect of kinetic control retraining on neck proprioception and functional outcome in patients with cervical radiculopathy.

Participants needed: 44
Trial details
Age: 40-55Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Apr 30, 2025Locations: 1
Eligibility criteria

Forty Four patients suffering from chronic cervical unilateral radiculopathy (sy... [+3]

Cervical myelopathy with evidence of pyramidal, posterior column, and or spinoth... [+6]

Status: Recruiting

Predictors of Response to Manual Physiotherapy Using Somatosensory Profiles in Patients With Cervicobrachial Pain

The goal of this clinical trial is to investigate about the characteristics that predict response to physiotherapy treatment in patients with nerve related neck arm pain. The main question to answer is whether there is a subgroup that responds better to physiotherapy treatment. Participants will be assessed for clinical and neurophysiological characteristics prior to treatment. Afterwards they will receive 6 sessions of manual physiotherapy treatment along with home nerve gliding exercises once a week. Baseline measurements will be taken again after treatment to know if there have been any changes.

Participants needed: 91
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: University of DeustoUpdated: Mar 26, 2025Locations: 1
Eligibility criteria

Subjects with unilateral cervicobrachial pain

Signs of severe disease, cervical myelopathy, tumour, rheumatic diseases or a ne... [+2]

Status: Not yet recruiting

Effect of Kinetic Control Training on Flexion Relaxation Phenomenon and Craniovertebral Angle in Cervical Radiculopathy Patients

The purpose of the study is to determine the effect of kinetic control training on flexion relaxation phenomenon and craniovertebral angle in patients with cervical radiculopathy.

Participants needed: 60
Trial details
Age: 40-55Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Dec 24, 2024Locations: 1
Eligibility criteria

Patients will be referred from neurologist with the diagnosis cervical spondylos... [+6]

Spinal canal stenosis. [+5]

Status: Recruiting

High Tone Power Therapy on Neck Pain and Proprioception in Cervical Radiculopathy

To investigate the Effect of High Tone Power Therapy on Neck Pain and Proprioception in Cervical Radiculopathy Patients.

Participants needed: 42
Trial details
Age: 35-50Biological sex: AllType: InterventionalSponsor: October 6 UniversityUpdated: Nov 27, 2024Locations: 1
Eligibility criteria

Their ages range from 35 to 50 years. [+5]

Any other musculoskeletal disorders of the spine or upper extremity [+5]

Status: Recruiting

Functioning in Individuals with Cervical Radiculopathy After Posterior Cervical Decompression

Compression on structures, as spinal nerves, in the cervical spine can cause cervical radiculopathy which leads to pain, disability, and reduced quality of life for the affected individual. Cervical foraminotomy with our without laminectomy are common posterior decompression surgical techniques for treating cervical radiculopathy. There is a lack of knowledge regarding function in patients with cervical radiculopathy after posterior cervical decompression. The aim with this study is to study pain, function, psychosocial factors, and health related quality of life after posterior cervical decompression in patients with cervical radiculopathy. This is a prospective multicenter longitudinal observational cohort study with follow-up at three, 12- and 24 months postoperative. A total of 154 individuals scheduled to undergo foraminotomy with our without laminectomy due to cervical radiculopathy will be included. Primary outcome is neck-specific function measured with the Neck Disability Index. Data will be collected preoperatively and at three, 12 and 24 months with electronic questionnaire.

Participants needed: 154
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: Linkoeping UniversityUpdated: Nov 25, 2024Locations: 3
Eligibility criteria

Cervical radiculopathy, confirmed by MRI images (or alternative neuroradiologica... [+3]

Nurick score 2 or more (to exclude individuals with moderate to high myelopathy) [+8]