Health Trials

Chromosomal Instability

2

Review clinical trials related to Chromosomal Instability. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

Participants needed: 200
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Volastra Therapeutics, Inc.Updated: Nov 4, 2025Locations: 14
Eligibility criteria

All Parts: Age ≥ 18 years, ECOG Performance Status ≤ 1, at least 1 site of measu... [+2]

MSI-H, dMMR, POLE gene hotspot mutated, or known hypermutator phenotype [+6]

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Status: Not yet recruiting

Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

The objective is to understand the relationship between TP53 mutation, MSS and chromosome instability in endometrial cancer and the effect on clinical prognosis.We will collect a small amount of tumor tissue samples. NGS panel detection and WGD/AS analysis were performed on the tissue. Paracancer tissue was used as a negative control and relevant information in medical records during the operation. Then we will collect clinical diagnosis and disease information through telephone follow-up after the completion of the operation.

Participants needed: 110
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Peking Union Medical College HospitalUpdated: Jul 26, 2024
Eligibility criteria

willing to participate in the study and sign the informed consent [+5]

Received chemotherapy within 14 days prior to sample collection, or received ant... [+2]

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