Chronic Low Back and Leg Pain

2

Review clinical trials related to Chronic Low Back and Leg Pain. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

The Lumbar Adjacent Segment Stenosis Trial

The goal of this clinical trial is to learn if there are differences in the effectiveness of decompression surgery alone versus decompression combined with extended fusion in patients with a previous lumbar spinal fusion who now present with symptoms of lumbar adjacent segment stenosis (LASS). The main questions it aims to answer are: * Does decompression alone differ from decompression combined with extended fusion with regard to clinical outcomes two years after surgery? * Are there any clinical or radiological characteristics that can predict better or worse outcomes two years after surgery? * Are there any differences between the treatment groups in terms of health economics? Researchers will compare decompression surgery alone versus decompression combined with extended fusion to see if there are any differences in treatment effect. Participants will: * Be randomized to one of the two surgical procedures * Visit the clinic four times postoperatively (at three months, 1, 2 and 5 years) for checkups and tests * Respond to questionnaires before surgery, and three months, 1, 2 and 5 years postoperatively

Participants needed: 192
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Oslo University HospitalUpdated: Jun 26, 2026Locations: 3
Eligibility criteria

Clinical symptoms of spinal stenosis, defined as neurogenic claudication or radi... [+7]

Previous surgery at the actual adjacent stenotic level. [+15]

Status: Recruiting

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.

Participants needed: 100
Trial details
Phase: Early Phase 1Age: 21-65Biological sex: AllType: InterventionalSponsor: University of California, San DiegoUpdated: Jun 3, 2026Locations: 1
Eligibility criteria

Between 21-65 years old [+11]

Active pulmonary disease [+16]