Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.
Between 21-65 years old
Currently 30 days cannabis free
Lower back pain for three months or more
Are not taking opioids
Active pulmonary disease
Allergy or past adverse effects or negative past experiences from cannabis
Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone
Any significant illness, including cardiovascular disease, diabetes, renal and liver disease.